Loss of laminin-γ1 in PDGFRβ+ cells impairs microvascular function and cognition. Ruan et al
Published: 19 March 2026| Version 1 | DOI: 10.17632/t8hszf89km.1
Contributors:
Jingsong Ruan, , Cecilia Martin, , , Description
Using mutant mice with laminin-γ1 deficiency in PDGFRβ+ cells, we investigated the functions of PDGFRβ+ cell-derived laminin-γ1 in blood-brain barrier integrity maintenance, pericyte number, basal lamina thickness, brain stiffness, CSF influx/brain clearance, synaptic loss, and cognitive function in an age-dependent manner. The raw data and unprocessed Western Blot images are provided here.
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Institutions
- University of South FloridaFlorida, Tampa
- Seattle Children's Research InstituteWashington, Seattle
Categories
Laminin, Blood-Brain Barrier, Cognitive Impairment, Stiffness, Pericyte, Cerebral Small Vessel Disease
Funders
- National Institutes of HealthUnited States Department of Health and Human ServicesBethesdaGrant ID: R01AG065345
- National Institutes of HealthUnited States Department of Health and Human ServicesBethesdaGrant ID: R01NS134134
- National Institutes of HealthUnited States Department of Health and Human ServicesBethesdaGrant ID: R01HL146574
- National Institutes of HealthUnited States Department of Health and Human ServicesBethesdaGrant ID: R21AG091884